Unravel the role of ESCRT in chromosome fragmentation
Membranes are important to protect DNA. Among key actors hosted by membranes, the protein ESCRT intervenes in cell surviving processes by closing holes in membranes. Our work investigates a new role of nuclear ESCRT that might be involved in chromosomal stability. Then, we propose to elucidate the DNA damage response and the role of ESCRT in this pathway, especially in the DNA repair pathway.